題  目：Sample Size and Power Calculations with Win Measures Based on Hierarchical Endpoints——In Memory of Professor Pan Wenxi

内容簡介：Win measures, such as win ratio, win odds, net benefit, and desirability of outcome ranking (DOOR), have become popular approaches for the analysis of hierarchical endpoints in clinical studies. Sample size and power calculations with win measures based on hierarchical endpoints are often reliant on simulation studies, which can be cumbersome. Existing sample size and powerformulas require investigators to specify clinically significant and meaningful magnitudes of winmeasures and the probability of ties—a task that is challenging to elicit from prior publishedliterature or preliminary data. In this talk, we provide sample size and power calculation formulasfor the four aforementioned win measures. To facilitate formula-based sample size or power calculations, we offer formulas to compute overall win measures and the overall probability of ties. These can be derived using the specification of marginal win measures and marginal probability of ties, which are readily available from clinical investigators or literature. The latter formulas introduce a novel approach to specify meaningful and justifiable magnitudes of win measures and the probability of ties. Consequently, they can be readily employed to evaluate thestatistical power based on the number of multiple endpoints, their ordering, and types. Our extensive simulation studies demonstrate that the power estimations based on these formulas are often similar to the simulated powers for any type of correlated hierarchical endpoints. We illustrate the usefulness of our formulas by utilizing data from existing trials with different types of hierarchical endpoints.

報告人：HuimanXie Barnhart（謝慧滿）

報告人簡介：1983年獲得華南師範大學數學學士學位，1986年獲得太阳集团app首页數學碩士學位，1992年獲得匹茲堡大學統計學博士學位，1992-2003 年，擔任埃默裡大學生物統計系教授，2003 年至今，擔任杜克大學生物統計與生物信息學系教授，目前是杜克大學的詹姆斯·B·杜克傑出教授，并擔任該校生物統計與生物信息學系的副主席，負責指導和發展教職員工。她還是杜克臨床研究所的主要成員。因其在可靠性評估、臨床試驗和隊列研究的卓越領導能力、以及對下一代生物統計學家的教育和指導方面有影響力的貢獻，她被授予美國統計協會會士榮譽。她目前擁有超過190 篇經過同行評審的期刊文章。她研究興趣包括：統計方法學、臨床試驗設計方法、臨床研究生物統計學，在肝損傷、心血管成像、放射學成像、心血管疾病、腎髒疾病、生殖醫學、帕金森病、老齡化等多個臨床領域開展的合作研究。她對教育、指導和研究的奉獻将不斷塑造着生物統計學領域。

時  間：2024年6月14日（周五）上午10：00開始

地  點：太阳集团app首页石牌校區南海樓224數學系會議室

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